Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12268288 | 0.92 | SOS1 (0.34) | SOS1SOS2 | |
| SCHEMBL20148741 | 0.86 | SOS1 (0.37) | SOS1SOS2 | |
| SCHEMBL22024162 | 0.86 | SOS1 (0.35) | SOS1SOS2 | |
| SCHEMBL23182189 | 0.86 | SOS1 (0.39) | SOS1SOS2 | |
| SCHEMBL17886522 | 0.83 | SOS1 (0.36) | SOS1SOS2 | |
| SCHEMBL19498050 | 0.83 | CRHBP (0.38) | SOS1SOS2 | |
| SCHEMBL24581323 | 0.81 | CRHBP (0.32) | — | |
| SCHEMBL20148742 | 0.76 | GRIN2D (0.41) | — | |
| SCHEMBL12563430 | 0.76 | GRIN2D (0.41) | SOS1SOS2 | |
| SCHEMBL1753460 | 0.74 | SOS1 (0.39) | SOS1SOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210186959-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA, INC. | 2021-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210186959-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, BRAF | SOS1 566/4885SOS2 1055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.