Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 3/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SCARB1 | Q8WTV0 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28962269 | 0.86 | TEAD1 (0.47) | KDM4EPDE7AALDH1A1HPGDHSD17B10 | |
| SCHEMBL23535749 | 0.85 | KDM4E (0.40) | KDM4ENPC1RAB9AHTR7RPS6KB1 | |
| SCHEMBL28962406 | 0.85 | CHRNB2 (0.40) | KDM4ENPC1RAB9ARPS6KB1ALDH1A1 | |
| SCHEMBL30159583 | 0.85 | KDM4E (0.40) | KDM4ENPC1RAB9AHTR7RPS6KB1 | |
| SCHEMBL23535820 | 0.85 | KDM4E (0.43) | KDM4ERAB9AHTR7RPS6KB1ALDH1A1 | |
| SCHEMBL30159511 | 0.85 | KDM4E (0.43) | KDM4ERAB9AHTR7RPS6KB1ALDH1A1 | |
| SCHEMBL23535751 | 0.84 | KDM4E (0.39) | KDM4ENPC1RAB9AHTR7RPS6KB1 | |
| SCHEMBL28962407 | 0.83 | NPC1 (0.39) | KDM4ENPC1RAB9AHTR7RPS6KB1 | |
| SCHEMBL30864306 | 0.81 | KDM4E (0.43) | KDM4ENPC1RAB9AHTR7RPS6KB1 | |
| SCHEMBL23559846 | 0.79 | AXL (0.43) | KDM4ENPC1RAB9ARPS6KB1PDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127166-A1 | INHIBITORS OF ENL/AF9 YEATS | THE ROCKEFELLER UNIVERSITY (US) | 2021-06-24 | — | — | WO | disclosed |