Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 5/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25015127 | 0.87 | KDM4E (0.41) | KDM4EALDH1A1HSD17B10 | |
| SCHEMBL30040739 | 0.78 | HCAR3 (0.55) | KDM4ESLC22A12TDP1HCAR3TBXAS1 | |
| SCHEMBL23535727 | 0.78 | HCAR3 (0.55) | KDM4ESLC22A12TDP1HCAR3TBXAS1 | |
| SCHEMBL13516579 | 0.76 | TDP1 (0.46) | KDM4ESLC22A12TDP1HCAR3TBXAS1 | |
| SCHEMBL20176288 | 0.75 | MAPK8 (0.39) | ALDH1A1HTT | |
| SCHEMBL15660855 | 0.75 | ADORA2A (0.56) | KDM4ESLC22A12HCAR3HPGDALDH1A1 | |
| SCHEMBL15970806 | 0.75 | HCAR3 (0.55) | KDM4ESLC22A12TDP1HCAR3HPGD | |
| SCHEMBL23535775 | 0.73 | HCAR3 (0.43) | KDM4ESLC22A12TDP1HCAR3HPGD | |
| SCHEMBL730542 | 0.73 | HTT (0.58) | KDM4ESLC22A12HPGDALDH1A1HTT | |
| SCHEMBL30040207 | 0.73 | HCAR3 (0.43) | KDM4ESLC22A12TDP1HCAR3HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127166-A1 | INHIBITORS OF ENL/AF9 YEATS | THE ROCKEFELLER UNIVERSITY (US) | 2021-06-24 | — | — | WO | disclosed |