Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Clofibrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA known ✓ | Q07869 | 7/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | HTR2A | P28223 | 2/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | FBP1 | P09467 | 5/20 | 0.57 |
| ▸ | PPARG | P37231 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | CNR1 | P21554 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clofibrate SCHEMBL3953607 | 1.00 | PPARA (1.00) | PPARACYP1A2CYP3A4ABCB11TSHR | |
| Clofibrate SCHEMBL29262880 | 0.98 | PPARA (0.97) | PPARACYP1A2CYP3A4ABCB11TSHR | |
| Clofibrate SCHEMBL5605019 | 0.98 | PPARA (0.97) | PPARACYP1A2CYP3A4ABCB11TSHR | |
| Clofibrate SCHEMBL3345 | 0.98 | PPARA (0.97) | PPARACYP1A2CYP3A4ABCB11TSHR | |
| Clofibrate SCHEMBL11184809 | 0.98 | PPARA (0.97) | PPARACYP1A2CYP3A4ABCB11TSHR | |
| Clofibrate SCHEMBL11187010 | 0.98 | PPARA (0.97) | PPARACYP1A2CYP3A4ABCB11TSHR | |
| Clofibrate SCHEMBL11180679 | 0.98 | PPARA (0.97) | PPARACYP1A2CYP3A4ABCB11TSHR | |
| Clofibrate SCHEMBL11175123 | 0.97 | PPARA (0.94) | PPARACYP1A2CYP3A4ABCB11TSHR | |
| Clofibrate SCHEMBL28086141 | 0.97 | PPARA (0.94) | PPARACYP1A2CYP3A4ABCB11TSHR | |
| SCHEMBL21992458 | 0.95 | PPARA (0.91) | PPARACYP1A2CYP3A4ABCB11TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 42287 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116182901-B | Method for analyzing intersection error of photoelectric theodolite and fusing intersection results in rapid optimization mode | 63610 troops of the Chinese PLA (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122084896-A | Rapid screening quantitative detection method for salmonella in grease feed additive | — | 2026-05-26 | — | — | CN | claimed |
| WO-2026103459-A1 | BGP ANOMALOUS ROUTE IDENTIFICATION METHOD AND APPARATUS, DEVICE AND MEDIUM | 天翼安全科技有限公司 | 2026-05-21 | — | — | WO | claimed |
| CN-122045132-A | Response request arbitration method, device, electronic equipment, chip and medium | 深圳江原科技有限公司 | 2026-05-15 | — | — | CN | claimed |
| WO-2026087680-A1 | TREATMENT FOR CARDIOVASCULAR DISEASE | SAPREME TECHNOLOGIES B.V. (NL) | 2026-04-30 | — | — | WO | claimed |
| US-20260108482-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS INC (US) | 2026-04-23 | — | — | US | claimed |
| US-20260103499-A1 | BIOREVERSABLE PROMOIETIES FOR NITROGEN-CONTAINING AND HYDROXYL-CONTAINING DRUGS | HAN JIE (US) | 2026-04-16 | — | — | US | claimed |
| EP-4725479-A1 | PPAR AGONISTS FOR TREATMENT OF DISEASES ASSOCIATED WITH AATD | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2026-04-15 | — | — | EP | claimed |
| EP-4724049-A1 | MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF | Catalent Ontario Limited (CA) | 2026-04-15 | — | — | EP | claimed |
| US-12582626-B2 | Methods and compositions for treating cancer | The Wister Institute of Anatomy and Biology (US) | 2026-03-24 | — | — | US | claimed |
| EP-0006305-B1 | DERIVATIVES OF 4,5-DIHYDRO-4-OXOFURAN-2-CARBOXYLIC ACID, ESPECIALLY FOR USE AS HYPOLIPIDEMIC AGENTS, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, TETRAHYDROPYRAN-2,3,5-TRIONES USEFUL IN THE PREPARATION OF THE SAID DERIVATIVES AND A PROCESS FOR PREPARING THESE TETRAHYDROPYRAN-2,3,5-TRIONES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-08-11 | — | — | EP | claimed |
| EP-0010460-B1 | PYRROLIDINE-2-METHANOL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | PHARMUKA LABORATOIRES (FR) | 1982-01-27 | — | — | EP | claimed |
| EP-0036218-A2 | Salts of the 3-hydroxy quinuclidine esters of a phenoxycarboxylic acid, a process for the preparation thereof, and related pharmaceutical compositions | D and D S.r.l. (IT) | 1981-09-23 | — | — | EP | claimed |
| WO-1981002295-A1 | PHENOXYISOBUTYRATES OF MOROXYDIN AND DRUGS CONTAINING THEM | MOREAU P | 1981-08-20 | — | — | WO | claimed |
| US-4250191-A | ADMINISTERING A PHENOXYACETIC ACID DERIVATIVE | EDWARDS K DAVID | 1981-02-10 | — | — | US | claimed |
| US-4244958-A | Hypolipidemic derivatives of 4,5-dihydro-4-oxofuran-2-carboxylic acid | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-01-13 | — | — | US | claimed |
| WO-1980000025-A1 | DERIVATIVES OF 4,5-DIHYDRO-4-OXOFURAN-2-CARBOXYLIC ACID,PREPARATIONS AND USE THEREOF AND TETRAHYDROPYRAN-2,3,5-TRIONE INTERMEDIATES | AMERICAN HOME PROD (US) | 1980-01-10 | — | — | WO | claimed |
| EP-0006305-A1 | Derivatives of 4,5-dihydro-4-oxofuran-2-carboxylic acid, especially for use as hypolipidemic agents, processes for their preparation, pharmaceutical compositions comprising them, tetrahydropyran-2,3,5-triones useful in the preparation of the said derivatives and a process for preparing these tetrahydropyran-2,3,5-triones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-01-09 | — | — | EP | claimed |
| US-4156003-A | Treatment of hypertension with combination of clofibrinic acid or clofibrate with cinnarizine | LUDWIG MERCKLE K.G., CHEM. PHARM. FABRIK (DE) | 1979-05-22 | — | — | US | claimed |
| US-4013773-A | VITAMIN E ACETATE OR CLOFIBRATE AND CALCIUM LACTATE HYDRATE | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JA) | 1977-03-22 | — | — | US | claimed |