Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Clofibrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA known ✓ | Q07869 | 7/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.97 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.97 |
| ▸ | TSHR | P16473 | 2/20 | 0.97 |
| ▸ | HTR2A | P28223 | 2/20 | 0.97 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.97 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | FBP1 | P09467 | 5/20 | 0.56 |
| ▸ | PPARG | P37231 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | CNR1 | P21554 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clofibrate SCHEMBL2356 | 0.98 | PPARA (1.00) | PPARACYP1A2CYP3A4ABCB11TSHR | |
| Clofibrate SCHEMBL3953607 | 0.98 | PPARA (1.00) | PPARACYP1A2CYP3A4ABCB11TSHR | |
| Clofibrate SCHEMBL11184809 | 0.97 | PPARA (0.97) | PPARACYP1A2CYP3A4ABCB11TSHR | |
| Clofibrate SCHEMBL29262880 | 0.97 | PPARA (0.97) | PPARACYP1A2CYP3A4ABCB11TSHR | |
| Clofibrate SCHEMBL3345 | 0.97 | PPARA (0.97) | PPARACYP1A2CYP3A4ABCB11TSHR | |
| Clofibrate SCHEMBL11187010 | 0.97 | PPARA (0.97) | PPARACYP1A2CYP3A4ABCB11TSHR | |
| Clofibrate SCHEMBL11180679 | 0.97 | PPARA (0.97) | PPARACYP1A2CYP3A4ABCB11TSHR | |
| Clofibrate SCHEMBL11175123 | 0.95 | PPARA (0.94) | PPARACYP1A2CYP3A4ABCB11TSHR | |
| Clofibrate SCHEMBL28086141 | 0.95 | PPARA (0.94) | PPARACYP1A2CYP3A4ABCB11TSHR | |
| SCHEMBL21992458 | 0.94 | PPARA (0.91) | PPARACYP1A2CYP3A4ABCB11TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111107745-B | Fungicidal compositions | 先正达参股股份有限公司 | 2021-12-07 | — | — | CN | claimed |
| CN-101974034-B | Method for synthesizing flavone alkyl phosphate compound and application thereof in cholesterol esterase inhibitor medicine | UNIV HUNAN AGRICULTURAL | 2012-05-30 | — | — | CN | disclosed |
| CN-102451161-A | Dispersible tablets containing cholesterol absorption inhibitor and lipid regulating drug, and application thereof | LIYAN WANG | 2012-05-16 | — | — | CN | disclosed |
| CN-1903364-B | Medicine composition containing inhibitor of angiotonase and phenoxy acid compounds | ANHUI MODERN CHINESE MEDICINE RES CT | 2011-06-22 | — | — | CN | disclosed |
| CN-101974034-A | Method for synthesizing flavone alkyl phosphate compound and application thereof in cholesterol esterase inhibitor medicine | GUOPING PENG | 2011-02-16 | — | — | CN | disclosed |
| CN-101912612-A | Dispersible tablet containing fibrate and statin drug and application thereof | FEI LIN | 2010-12-15 | — | — | CN | disclosed |
| CN-101897685-A | Composition containing sibutramine and fibrate lipid-lowering drugs | BEIJING AOSA PHARMED RES CT CO LTD | 2010-12-01 | — | — | CN | disclosed |
| CN-100584382-C | Medicinal composition containing angiotensin II receptor agonist and fibric acid compound | ANHUI XIANDAI TCM RES CT | 2010-01-27 | — | — | CN | disclosed |
| CN-100531729-C | Composition containing fibrate drug and taurine | BEIJING HUAANFO PHARMACEUTICAL (CN) | 2009-08-26 | — | — | CN | disclosed |
| US-20070134324-A1 | THERAPEUTIC COMBINATIONS | MESSADEK JALLAL | 2007-06-14 | — | — | US | disclosed |
| CN-1903364-A | Medicine composition contg. inhibitor of angiotonase and phenoxy acid compounds | ANHUI PROV MODERN TRADITIONAL (CN) | 2007-01-31 | — | — | CN | disclosed |
| CN-1891297-A | Medicinal composition containing angiotensin II receptor agonist and fibric acid compound | XIANDAI TCM RES CT ANHUI PROV (CN) | 2007-01-10 | — | — | CN | disclosed |
| CN-1850063-A | Composition containing fibrate drug and taurine | BEIJING HUAANFO PHARMACEUTICAL (CN) | 2006-10-25 | — | — | CN | disclosed |
| CN-1827170-A | Composition containing dihydropyridin type of calcium antagonists and fibrates medicine | BEIJING HUAANFU MEDICINE RES C (CN) | 2006-09-06 | — | — | CN | disclosed |