Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | DAO | P14920 | 1/20 | 0.67 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.67 |
| ▸ | CES1 | P23141 | 5/20 | 0.56 |
| ▸ | CES2 | O00748 | 3/20 | 0.56 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL1681320 | 1.00 | TSHR (0.67) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL9563651 | 1.00 | TSHR (0.67) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL2411132 | 1.00 | TSHR (0.67) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL8432316 | 1.00 | TSHR (0.67) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL11031846 | 1.00 | TSHR (0.67) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL27621 | 1.00 | TSHR (0.67) | TSHRDAONAPRTCES1CES2 | |
| Terephthalic Acid SCHEMBL11490240 | 0.90 | TSHR (0.63) | TSHRDAONAPRTCES1CES2 | |
| Terephthalic Acid SCHEMBL8506032 | 0.90 | TSHR (0.63) | TSHRDAONAPRTCES1CES2 | |
| Terephthalic Acid SCHEMBL2687529 | 0.90 | TSHR (0.63) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL1785542 | 0.88 | TSHR (0.52) | TSHRDAONAPRTCES1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478694-B1 | POLYETHERIMIDE COMPOSITION, METHOD, AND ARTICLE | SABIC INNOVATIVE PLASTICS IP (NL) | 2011-08-10 | — | — | EP | disclosed |
| EP-1478694-A1 | POLYETHERIMIDE COMPOSITION, METHOD, AND ARTICLE | GENERAL ELECTRIC COMPANY (US) | 2004-11-24 | — | — | EP | disclosed |
| US-6753365-B2 | MIXTURE WITH ACID ADJUVANT | GENERAL ELECTRIC COMPANY | 2004-06-22 | — | — | US | disclosed |
| US-20030171469-A1 | Mixture with acid adjuvant | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2003-09-11 | — | — | US | disclosed |
| WO-2003070828-A1 | POLYETHERIMIDE COMPOSITION, METHOD, AND ARTICLE | GENERAL ELECTRIC COMPANY (US) | 2003-08-28 | — | — | WO | disclosed |