Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.69 |
| ▸ | PTK2B | Q14289 | 7/20 | 0.61 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.61 |
| ▸ | MET | P08581 | 9/20 | 0.55 |
| ▸ | AXL | P30530 | 2/20 | 0.54 |
| ▸ | MERTK | Q12866 | 1/20 | 0.54 |
| ▸ | EIF2AK3 | Q9NZJ5 | 2/20 | 0.52 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL200000 | 0.86 | SYK (0.75) | SYKPTK2BPTK2METAXL | |
| SCHEMBL200020 | 0.85 | PTK2B (0.79) | SYKPTK2BPTK2METAXL | |
| SCHEMBL201489 | 0.85 | SYK (0.68) | SYKPTK2BPTK2METAXL | |
| SCHEMBL199798 | 0.85 | SYK (0.81) | SYKPTK2BPTK2METAXL | |
| SCHEMBL200792 | 0.85 | SYK (0.73) | SYKPTK2BPTK2METAXL | |
| SCHEMBL199499 | 0.84 | PTK2B (0.79) | SYKPTK2BPTK2METAXL | |
| SCHEMBL2356509 | 0.81 | SYK (0.69) | SYKPTK2BPTK2METAXL | |
| SCHEMBL199512 | 0.79 | SYK (0.63) | SYKPTK2BPTK2METAXL | |
| SCHEMBL199755 | 0.78 | SYK (0.73) | SYKPTK2BPTK2METAXL | |
| SCHEMBL12993745 | 0.76 | SYK (0.64) | SYKPTK2BPTK2METAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349328-A1 | METHODS FOR THE TREATMENT OF CANCER | LUDWIG INSTITUTE FOR CANCER RESEARCH (US) | 2011-08-03 | — | — | EP | claimed |
| WO-2010039248-A1 | METHODS FOR THE TREATMENT OF CANCER | LUDWIG INSTITUTE FOR CANCER RESEARCH (US) | 2010-04-08 | — | — | WO | claimed |