Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 3/20 | 0.35 |
| ▸ | JAK3 | P52333 | 3/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 3/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | CTSE | P14091 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23564734 | 0.90 | HCAR1 (0.38) | HCAR1CHRM2CHRM4CHRM1JAK2 | |
| SCHEMBL23564944 | 0.83 | HCAR1 (0.42) | HCAR1ALOX5APFEN1 | |
| SCHEMBL21853463 | 0.83 | HCAR1 (0.42) | HCAR1ALOX5APFEN1 | |
| SCHEMBL31708682 | 0.76 | HCAR1 (0.55) | HCAR1CHRM2CHRM4CHRM1JAK2 | |
| SCHEMBL27186139 | 0.66 | HCAR1 (0.39) | HCAR1JAK2JAK3JAK1MTOR | |
| SCHEMBL24268157 | 0.65 | HCAR1 (0.40) | HCAR1JAK2JAK3JAK1CTSE | |
| SCHEMBL16332535 | 0.65 | HCAR1 (0.47) | HCAR1JAK2JAK3MTOR | |
| SCHEMBL16332914 | 0.65 | HCAR1 (0.47) | HCAR1JAK2JAK3CTSEBACE1 | |
| SCHEMBL30910230 | 0.64 | MAP4K1 (0.38) | HCAR1MTORAKT1GSK3BDYRK1A | |
| SCHEMBL30459373 | 0.62 | JAK2 (0.44) | HCAR1CHRM2CHRM4CHRM1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127459-A1 | GPR139 RECEPTOR MODULATORS | BLACKTHORN THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |