Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA1 | Q92743 | 2/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.32 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.32 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.32 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.32 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.32 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25444900 | 0.91 | FOLH1 (0.31) | — | |
| SCHEMBL25444898 | 0.90 | FOLH1 (0.30) | — | |
| SCHEMBL23051801 | 0.86 | CACNA1B (0.33) | HTRA1PSMB5PSMB1PSMB8PSMB9 | |
| SCHEMBL23080795 | 0.84 | FOLH1 (0.30) | — | |
| SCHEMBL25495671 | 0.81 | PTPN1 (0.31) | PSMB5PSMB8PSMB9PSMB10 | |
| SCHEMBL25499826 | 0.79 | CHRM5 (0.34) | — | |
| SCHEMBL25495648 | 0.77 | USP2 (0.33) | — | |
| SCHEMBL25171446 | 0.75 | PSMB10 (0.42) | HTRA1PSMB5PSMB1PSMB8PSMB9 | |
| SCHEMBL25171447 | 0.75 | PSMB10 (0.42) | HTRA1PSMB5PSMB1PSMB8PSMB9 | |
| SCHEMBL25171448 | 0.75 | PSMB10 (0.42) | HTRA1PSMB5PSMB1PSMB8PSMB9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127460-A1 | PCSK9 ANTAGONIST COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2021-06-24 | — | — | WO | disclosed |