Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25444898 | 0.94 | FOLH1 (0.30) | FOLH1KMT2A | |
| SCHEMBL23565704 | 0.91 | HTRA1 (0.33) | — | |
| SCHEMBL23080795 | 0.86 | FOLH1 (0.30) | FOLH1 | |
| SCHEMBL25499826 | 0.83 | CHRM5 (0.34) | KMT2A | |
| SCHEMBL23051801 | 0.81 | CACNA1B (0.33) | KMT2A | |
| SCHEMBL25495671 | 0.79 | PTPN1 (0.31) | — | |
| SCHEMBL25495648 | 0.74 | USP2 (0.33) | — | |
| SCHEMBL25444903 | 0.72 | MMP1 (0.43) | — | |
| SCHEMBL23643226 | 0.68 | MMP1 (0.43) | KMT2A | |
| SCHEMBL23538085 | 0.68 | CA2 (0.40) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230144324-A1 | PCSK9 ANTAGONIST COMPOUNDS | MERCK SHARP & DOHME LLC | 2023-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230144324-A1 | PCSK9 ANTAGONIST COMPOUNDS | PCSK9, PCSK7, PCSK6 | FOLH1 1108/4885KMT2A 1269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.