SCHEMBL2356718

SCHEMBL2356718

C=CCNC(=O)C(=O)N(CC=C)CC=C

nearest known ligand 0.42

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
TSHR P16473 2/20 0.42
MAPT P10636 2/20 0.42
KMT2A Q03164 1/20 0.39
FAAH O00519 1/20 0.35
RAB9A P51151 2/20 0.35
KDM4E B2RXH2 2/20 0.34
HPGD P15428 1/20 0.33
CYP1A2 P05177 1/20 0.33
LMNA P02545 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3280089 0.83 ALDH1A1 (0.42) ALDH1A1SMN1; SMN2TSHRMAPTKMT2A
SCHEMBL28018915 0.82 KDM4E (0.35) ALDH1A1SMN1; SMN2TSHRMAPTKMT2A
SCHEMBL28558812 0.82 SMN1; SMN2 (0.41) ALDH1A1SMN1; SMN2TSHRMAPTKMT2A
SCHEMBL5695370 0.78 ALDH1A1 (0.45) ALDH1A1SMN1; SMN2TSHRMAPTKMT2A
SCHEMBL6708425 0.78 ALDH1A1 (0.45) ALDH1A1SMN1; SMN2TSHRMAPTKMT2A
SCHEMBL15068247 0.77 TSHR (0.43) ALDH1A1SMN1; SMN2TSHRMAPTKMT2A
SCHEMBL569156 0.77 ALDH1A1 (0.56) ALDH1A1SMN1; SMN2TSHRMAPTKMT2A
SCHEMBL4952777 0.77 TSHR (0.56) ALDH1A1SMN1; SMN2TSHRMAPTKMT2A
SCHEMBL4073329 0.73 SMN1; SMN2 (0.50) ALDH1A1SMN1; SMN2TSHRMAPTKMT2A
SCHEMBL11668092 0.72 ALDH1A1 (0.52) ALDH1A1SMN1; SMN2MAPTKMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2349276-A2 HIV INTEGRASE INHIBITORS Merck Sharp & Dohme Corp. (US) 2011-08-03 EP disclosed
WO-2010042392-A2 HIV INTEGRASE INHIBITORS MERCK & CO., INC. (US) 2010-04-15 WO disclosed
WO-2010042391-A2 HIV INTEGRASE INHIBITORS MERCK SHARP & DOHME CORP. (US) 2010-04-15 WO disclosed
EP-1453804-A2 CCR-3 RECEPTOR ANTAGONISTS VII F. Hoffmann-La Roche AG (CH) 2004-09-08 EP disclosed
WO-2003045917-A2 CCR-3 RECEPTOR ANTAGONISTS VII F. HOFFMANN-LAROCHE AG (CH) 2003-06-05 WO disclosed