Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | ITK | Q08881 | 3/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23567652 | 0.80 | AURKA (0.38) | AURKAMAPK10RIPK1HSD17B10PDE4D | |
| SCHEMBL23567665 | 0.77 | ITK (0.47) | AURKARIPK1MAPTKDM4EMEN1 | |
| SCHEMBL23565145 | 0.77 | ITK (0.47) | AURKARIPK1MAPTKDM4EMEN1 | |
| SCHEMBL25545776 | 0.77 | ITK (0.47) | AURKARIPK1MAPTKDM4EMEN1 | |
| SCHEMBL2471811 | 0.76 | AURKA (0.43) | AURKAMAPK10RIPK1HSD17B10PDE4D | |
| SCHEMBL19140049 | 0.75 | AURKA (0.44) | AURKAMAPK10RIPK1HSD17B10PDE4D | |
| SCHEMBL19140474 | 0.74 | KDM4E (0.45) | AURKAMAPK10RIPK1HSD17B10PDE4D | |
| SCHEMBL30587533 | 0.73 | ALDH1A1 (0.45) | AURKAMAPK10RIPK1HSD17B10MAPT | |
| SCHEMBL30092714 | 0.73 | AURKA (0.40) | AURKAMAPK10RIPK1HSD17B10PDE4D | |
| SCHEMBL4488956 | 0.72 | AURKA (0.38) | AURKAMAPK10RIPK1HSD17B10PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021124155-A1 | BENZIMIDAZOLE DERIVATIVES | PFIZER INC. (US) | 2021-06-24 | — | — | WO | disclosed |