Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 18/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.37 |
| ▸ | IL2 | P60568 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23524806 | 0.75 | HCAR2 (0.51) | ITKAURKALCKRIPK1 | |
| SCHEMBL23524945 | 0.75 | HCAR2 (0.51) | ITKAURKALCKRIPK1 | |
| SCHEMBL23567665 | 0.72 | ITK (0.47) | ITKAURKALCKRIPK1IL2 | |
| SCHEMBL23565145 | 0.72 | ITK (0.47) | ITKAURKALCKRIPK1IL2 | |
| SCHEMBL23567959 | 0.67 | HCAR2 (0.37) | ITKAURKARIPK1 | |
| SCHEMBL23567662 | 0.65 | — | — | |
| SCHEMBL23567650 | 0.61 | AURKA (0.39) | ITKAURKALCKRIPK1 | |
| SCHEMBL25321264 | 0.60 | HCAR2 (0.48) | — | |
| SCHEMBL731695 | 0.55 | — | — | |
| SCHEMBL14216992 | 0.55 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021124155-A1 | BENZIMIDAZOLE DERIVATIVES | PFIZER INC. (US) | 2021-06-24 | — | — | WO | disclosed |