Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2356843 | 1.00 | FPR2 (0.33) | FPR2CMKLR1FFAR1FFAR4NFKB1 | |
| Hydrochloric Acid SCHEMBL28843048 | 0.98 | FPR2 (0.33) | FPR2CMKLR1FFAR1FFAR4NFKB1 | |
| SCHEMBL2143102 | 0.82 | — | — | |
| SCHEMBL2143097 | 0.82 | — | — | |
| SCHEMBL2864017 | 0.82 | FPR2 (0.33) | FPR2CMKLR1FFAR1FFAR4NFKB1 | |
| SCHEMBL2828890 | 0.82 | FPR2 (0.33) | FPR2CMKLR1FFAR1FFAR4NFKB1 | |
| SCHEMBL15827689 | 0.82 | FPR2 (0.33) | FPR2CMKLR1FFAR1FFAR4NFKB1 | |
| SCHEMBL13021370 | 0.82 | FPR2 (0.33) | FPR2CMKLR1FFAR1FFAR4NFKB1 | |
| SCHEMBL2830306 | 0.82 | FPR2 (0.33) | FPR2CMKLR1FFAR1FFAR4NFKB1 | |
| SCHEMBL873097 | 0.77 | FFAR1 (0.33) | FFAR1FFAR4NFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350021-B1 | BRIDGED TETRAHYDRONAPHTHALENE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2013-03-20 | — | — | EP | claimed |
| EP-2350021-A1 | BRIDGED TETRAHYDRONAPHTHALENE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2011-08-03 | — | — | EP | claimed |
| WO-2010046855-A1 | BRIDGED TETRAHYDRONAPHTHALENE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-04-29 | — | — | WO | claimed |
| CN-118324762-A | Compounds and compositions for treating CNS disorders | 布鲁奥科制药有限公司 | 2024-07-12 | — | — | CN | disclosed |
| CN-114929235-A | Compounds and compositions for treating CNS disorders | 布鲁奥科制药有限公司 | 2022-08-19 | — | — | CN | disclosed |
| EP-2350021-B1 | BRIDGED TETRAHYDRONAPHTHALENE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2013-03-20 | — | — | EP | disclosed |
| EP-2350021-A1 | BRIDGED TETRAHYDRONAPHTHALENE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010046855-A1 | BRIDGED TETRAHYDRONAPHTHALENE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-04-29 | — | — | WO | disclosed |