Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13086734 | 0.85 | NPC1 (0.36) | LMNANPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL23534840 | 0.79 | KDM4E (0.51) | LMNARAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL25680979 | 0.75 | NPC1 (0.42) | LMNANPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL1993552 | 0.73 | TDP1 (0.44) | LMNARAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL23502135 | 0.71 | NPC1 (0.35) | LMNANPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL26859104 | 0.70 | SMN1; SMN2 (0.53) | LMNANPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL25017791 | 0.70 | KDM4E (0.38) | LMNANPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL24967875 | 0.69 | NPC1 (0.34) | LMNANPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL24869559 | 0.69 | NPC1 (0.39) | LMNANPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL12615901 | 0.69 | SMN1; SMN2 (0.51) | LMNANPC1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021126729-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-06-24 | — | — | WO | disclosed |