Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13086734 | 0.81 | NPC1 (0.36) | NPC1RAB9ASMN1; SMN2LMNAKDM4E | |
| SCHEMBL1993552 | 0.80 | TDP1 (0.44) | RAB9ASMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL10143654 | 0.79 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2LMNAKDM4E | |
| SCHEMBL23502135 | 0.77 | NPC1 (0.35) | NPC1RAB9ASMN1; SMN2LMNAKDM4E | |
| SCHEMBL25017791 | 0.76 | KDM4E (0.38) | NPC1RAB9ASMN1; SMN2LMNAKDM4E | |
| SCHEMBL25680999 | 0.76 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2LMNAKDM4E | |
| SCHEMBL25741795 | 0.76 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2LMNAKDM4E | |
| SCHEMBL23571997 | 0.75 | LMNA (0.32) | NPC1RAB9ASMN1; SMN2LMNAKDM4E | |
| SCHEMBL12615901 | 0.75 | SMN1; SMN2 (0.51) | NPC1RAB9ASMN1; SMN2LMNAKDM4E | |
| SCHEMBL20341670 | 0.74 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024137329-A1 | METHODS FOR THE SYNTHESIS OF COMPLEMENT FACTOR D INHIBITORS AND INTERMEDIATES THEREOF | ALEXION PHARMACEUTICALS, INC. (US) | 2024-06-27 | — | — | WO | disclosed |
| WO-2023114200-A2 | METHODS FOR THE SYNTHESIS OF COMPLEMENT FACTOR D INHIBITORS AND INTERMEDIATES THEREOF | ALEXION PHARMACEUTICALS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |
| WO-2023114198-A2 | METHODS FOR THE SYNTHESIS OF COMPLEMENT FACTOR D INHIBITORS | ALEXION PHARMACEUTICALS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |