Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.40 |
| ▸ | STS | P08842 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23817330 | 1.00 | HPGD (0.44) | HPGDRECQLEPHX1EPHX2USP2 | |
| SCHEMBL21111211 | 1.00 | HPGD (0.44) | HPGDRECQLEPHX1EPHX2USP2 | |
| SCHEMBL23578918 | 0.87 | HPGD (0.43) | HPGDRECQLEPHX1EPHX2USP2 | |
| SCHEMBL14671917 | 0.85 | HPGD (0.47) | HPGDRECQLEPHX1EPHX2USP2 | |
| SCHEMBL14671914 | 0.85 | HPGD (0.47) | HPGDRECQLEPHX1EPHX2USP2 | |
| SCHEMBL15105073 | 0.85 | HPGD (0.47) | HPGDRECQLEPHX1EPHX2USP2 | |
| SCHEMBL20709187 | 0.85 | HPGD (0.42) | HPGDRECQLEPHX1EPHX2USP2 | |
| SCHEMBL26630212 | 0.82 | STS (0.40) | HPGDRECQLEPHX1EPHX2GPR119 | |
| SCHEMBL23579228 | 0.82 | HPGD (0.44) | HPGDRECQLEPHX1EPHX2USP2 | |
| SCHEMBL29958797 | 0.82 | HPGD (0.44) | HPGDRECQLEPHX1EPHX2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4081515-A1 | INHIBITORS OF MUTANT FORMS OF EGFR | Blueprint Medicines Corporation (US) | 2022-11-02 | — | — | EP | disclosed |
| WO-2021133809-A1 | INHIBITORS OF MUTANT FORMS OF EGFR | BLUEPRINT MEDICINES CORPORATION (US) | 2021-07-01 | — | — | WO | disclosed |