Sugi Predict

Sugi Predict / Compounds / SCHEMBL21111211

SCHEMBL21111211

SCHEMBL21111211

COC1CCN(C(=O)OC(C)(C)C)CC1(F)F

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 1/20 0.44
▸ RECQL P46063 1/20 0.43
▸ EPHX1 P07099 1/20 0.43
▸ EPHX2 P34913 1/20 0.41
▸ USP2 O75604 1/20 0.41
▸ SMN1; SMN2 Q16637 1/20 0.41
▸ ALDH1A1 P00352 1/20 0.40
▸ GPR119 Q8TDV5 4/20 0.40
▸ STS P08842 2/20 0.40
▸ HSD17B10 Q99714 1/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ MAPT P10636 1/20 0.39
▸ THRB P10828 1/20 0.39
▸ PTPN2 P17706 1/20 0.39
▸ PTPN1 P18031 1/20 0.39
▸ PTPN6 P29350 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23578969 1.00 HPGD (0.44) HPGDRECQLEPHX1EPHX2USP2
SCHEMBL23817330 1.00 HPGD (0.44) HPGDRECQLEPHX1EPHX2USP2
SCHEMBL23578918 0.87 HPGD (0.43) HPGDRECQLEPHX1EPHX2USP2
SCHEMBL14671917 0.85 HPGD (0.47) HPGDRECQLEPHX1EPHX2USP2
SCHEMBL14671914 0.85 HPGD (0.47) HPGDRECQLEPHX1EPHX2USP2
SCHEMBL15105073 0.85 HPGD (0.47) HPGDRECQLEPHX1EPHX2USP2
SCHEMBL20709187 0.85 HPGD (0.42) HPGDRECQLEPHX1EPHX2USP2
SCHEMBL26630212 0.82 STS (0.40) HPGDRECQLEPHX1EPHX2GPR119
SCHEMBL23579228 0.82 HPGD (0.44) HPGDRECQLEPHX1EPHX2USP2
SCHEMBL29958797 0.82 HPGD (0.44) HPGDRECQLEPHX1EPHX2USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250289801-A1 EGFR INHIBITORS BLUEPRINT MEDICINES CORPORATION 2025-09-18 — — US disclosed
CN-115135642-B Inhibitors of EGFR mutant forms 缆图药品公司 2025-03-04 — — CN disclosed
US-12172983-B2 EGFR inhibitors BLUEPRINT MEDICINES CORPORATION (US) 2024-12-24 — — US disclosed
US-11718602-B2 EGFR inhibitors BLUEPRINT MEDICINES CORPORATION (US) 2023-08-08 — — US disclosed
US-20230056541-A1 EGFR INHIBITORS BLUEPRINT MEDICINES CORPORATION 2023-02-23 — — US disclosed
US-20230026209-A1 EGFR INHIBITORS BLUEPRINT MEDICINES CORPORATION 2023-01-26 — — US disclosed
CN-115135642-A Inhibitors of mutant forms of EGFR 缆图药品公司 2022-09-30 — — CN disclosed
US-11166954-B2 Dihydropyrimidine compound and preparation method and use thereof SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) 2021-11-09 — — US disclosed
US-11166954-B2 Dihydropyrimidine compound and preparation method and use thereof SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) 2021-11-09 — — US disclosed
CN-109790145-B Dihydropyrimidine compound and preparation method and application thereof 四川科伦博泰生物医药股份有限公司 2020-09-22 — — CN disclosed
US-20200253971-A1 DIHYDROPYRIMIDINE COMPOUND AND PREPARATION METHOD AND USE THEREOF SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) 2020-08-13 — — US disclosed
US-20200253971-A1 DIHYDROPYRIMIDINE COMPOUND AND PREPARATION METHOD AND USE THEREOF SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) 2020-08-13 — — US disclosed
US-10696669-B2 Dihydropyrimidine compound and preparation method and use thereof SICHUAN KELUN-BIOTECH BIOPHARMACEUTICALS CO., LTD. (CN) 2020-06-30 — — US disclosed
US-10696669-B2 Dihydropyrimidine compound and preparation method and use thereof SICHUAN KELUN-BIOTECH BIOPHARMACEUTICALS CO., LTD. (CN) 2020-06-30 — — US disclosed
US-20190225603-A1 DIHYDROPYRIMIDINE COMPOUND AND PREPARATION METHOD AND USE THEREOF SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) 2019-07-25 — — US disclosed
US-20190225603-A1 DIHYDROPYRIMIDINE COMPOUND AND PREPARATION METHOD AND USE THEREOF SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) 2019-07-25 — — US disclosed
EP-3508483-A1 DIHYDROPYRIMIDINE COMPOUND AND PREPARATION METHOD AND USE THEREOF Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) 2019-07-10 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11166954-B2 Dihydropyrimidine compound and preparation method and use thereof DPYD, DHPS, HPRT1 HPGD 158/4885RECQL 290/4885EPHX1 1213/4885
US-20190225603-A1 DIHYDROPYRIMIDINE COMPOUND AND PREPARATION METHOD AND USE THEREOF DPYD, TYMP, DHPS HPGD 381/4885RECQL 324/4885EPHX1 1221/4885
US-20230056541-A1 EGFR INHIBITORS EGFR, ERBB2, ERBB3 HPGD 3657/4885RECQL 4012/4885EPHX1 3888/4885
US-20230026209-A1 EGFR INHIBITORS EGFR, ERBB2, ERBB3 HPGD 3657/4885RECQL 4012/4885EPHX1 3888/4885
US-11718602-B2 EGFR inhibitors EGFR, ERBB2, ERBB3 HPGD 3657/4885RECQL 4012/4885EPHX1 3888/4885
US-20200253971-A1 DIHYDROPYRIMIDINE COMPOUND AND PREPARATION METHOD AND USE THEREOF DPYD, DHPS, HPRT1 HPGD 158/4885RECQL 290/4885EPHX1 1213/4885
US-12172983-B2 EGFR inhibitors EGFR, ERBB2, ERBB3 HPGD 3657/4885RECQL 4012/4885EPHX1 3888/4885
US-10696669-B2 Dihydropyrimidine compound and preparation method and use thereof DPYD, TYMP, DHPS HPGD 381/4885RECQL 324/4885EPHX1 1221/4885
US-20250289801-A1 EGFR INHIBITORS EGFR, ERBB2, ERBB3 HPGD 3657/4885RECQL 4012/4885EPHX1 3888/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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