Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7623081 | 0.85 | TYR (0.50) | HTTMAPK1HIF1ALMNATYR | |
| SCHEMBL2366994 | 0.84 | SLC6A2 (0.39) | ADRB2SLC6A4SLC6A3BRD4HSD17B10 | |
| SCHEMBL8171846 | 0.81 | SLC6A2 (0.41) | ADRB2SLC6A4SLC6A3TSHRSLC6A2 | |
| SCHEMBL27743458 | 0.81 | HSD17B10 (0.39) | ADRB2BRD4HSD17B10FFAR2TSHR | |
| SCHEMBL13631877 | 0.81 | HDAC8 (0.32) | SLC6A4SLC6A3TDP1SLC6A2LMNA | |
| SCHEMBL27555060 | 0.79 | HSD17B10 (0.38) | ADRB2SLC6A4SLC6A3BRD4HSD17B10 | |
| SCHEMBL9714748 | 0.79 | ESR1 (0.54) | SLC6A3HSD17B10HIF1ATDP1SLC6A2 | |
| SCHEMBL11285019 | 0.79 | L3MBTL1 (0.45) | TSHRMAPK1TDP1LMNATP53 | |
| SCHEMBL19060475 | 0.79 | CYP1A2 (0.38) | HSD17B10HPGD | |
| SCHEMBL9731920 | 0.79 | TDP1 (0.36) | HTTTDP1LMNAAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021133915-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) MODULATORS AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-07-01 | — | — | WO | disclosed |