Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.35 |
| ▸ | GCGR | P47871 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2358917 | 0.94 | MAPT (0.34) | MAPK14MAPTTP53MAPK1NPSR1 | |
| SCHEMBL2359451 | 0.93 | BRAF (0.35) | MAPK14MAPTTP53MAPK1KDM4E | |
| SCHEMBL2359750 | 0.91 | PPARG (0.34) | MAPK14MAPTTP53MAPK1KDM4E | |
| SCHEMBL14108522 | 0.90 | MAPK1 (0.37) | MAPK14MAPTTP53MAPK1NPSR1 | |
| SCHEMBL2315315 | 0.90 | BRAF (0.37) | MAPK14MAPTTP53MAPK1KDM4E | |
| SCHEMBL14719496 | 0.89 | BRAF (0.35) | MAPK14MAPTTP53MAPK1NPSR1 | |
| SCHEMBL2358799 | 0.89 | MAPK14 (0.39) | MAPK14MAPTTP53MAPK1NPSR1 | |
| SCHEMBL2359428 | 0.88 | MAPK14 (0.38) | MAPK14MAPTTP53MAPK1NPSR1 | |
| SCHEMBL2359221 | 0.86 | MAPK14 (0.38) | MAPK14MAPTTP53MAPK1NPSR1 | |
| SCHEMBL2316998 | 0.85 | MAPK14 (0.35) | MAPK14MAPTTP53MAPK1CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104958294-A | Sulfonamido derivatives of 3, 4-diarylpyrazoles as protein kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL | 2015-10-07 | — | — | CN | disclosed |
| WO-2011092088-A1 | SULFONAMIDO DERIVATIVES OF 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-08-04 | — | — | WO | disclosed |