Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.32 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.32 |
| ▸ | TUBB | P07437 | 1/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.32 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.32 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.32 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.32 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2358155 | 0.93 | MAPK14 (0.39) | BRAFMAPK3MAPK1MAPTKDM4E | |
| SCHEMBL2359750 | 0.91 | PPARG (0.34) | BRAFMAPK3MAPK1MAPTKDM4E | |
| SCHEMBL2358917 | 0.91 | MAPT (0.34) | BRAFMAPK3MAPK1MAPTKDM4E | |
| SCHEMBL14108522 | 0.91 | MAPK1 (0.37) | BRAFMAPK3MAPK1MAPTKDM4E | |
| SCHEMBL2315315 | 0.91 | BRAF (0.37) | BRAFMAPK3MAPK1MAPTKDM4E | |
| SCHEMBL2357717 | 0.88 | BRAF (0.34) | BRAFMAPK3MAPK1MAPK14FABP4 | |
| SCHEMBL2359292 | 0.88 | MAPK14 (0.35) | BRAFMAPK3MAPK1MAPTKDM4E | |
| SCHEMBL14719496 | 0.88 | BRAF (0.35) | BRAFMAPK3MAPK1MAPTKDM4E | |
| SCHEMBL2357132 | 0.85 | BRAF (0.34) | BRAFMAPK3MAPK1MAPTKDM4E | |
| SCHEMBL2316012 | 0.85 | BRAF (0.35) | BRAFMAPK3MAPK1MAPK14RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011092088-A1 | SULFONAMIDO DERIVATIVES OF 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-08-04 | — | — | WO | claimed |
| WO-2011092088-A1 | SULFONAMIDO DERIVATIVES OF 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-08-04 | — | — | WO | disclosed |