Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | ATR | Q13535 | 6/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.31 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.31 |
| ▸ | ATRIP | Q8WXE1 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23584749 | 0.93 | BRD4 (0.31) | BRD4ATR | |
| SCHEMBL23584771 | 0.90 | CSNK2A2 (0.35) | BRD4ATRSIRT2SIRT1SIRT3 | |
| SCHEMBL23584740 | 0.87 | SIRT2 (0.30) | SIRT2SIRT1SIRT3 | |
| SCHEMBL19344507 | 0.83 | BRD4 (0.31) | BRD4 | |
| SCHEMBL23584758 | 0.83 | DOT1L (0.33) | BRD4ATR | |
| SCHEMBL23584607 | 0.81 | — | — | |
| SCHEMBL23584623 | 0.80 | — | — | |
| SCHEMBL23584779 | 0.80 | — | — | |
| SCHEMBL19344519 | 0.78 | — | — | |
| SCHEMBL23584694 | 0.77 | CSNK2A2 (0.34) | SIRT2SIRT1SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |