⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23584740 | 0.93 | SIRT2 (0.30) | — | |
| SCHEMBL23584486 | 0.90 | DOT1L (0.33) | — | |
| SCHEMBL23584749 | 0.86 | BRD4 (0.31) | — | |
| SCHEMBL19344074 | 0.84 | — | — | |
| SCHEMBL23584694 | 0.83 | CSNK2A2 (0.34) | — | |
| SCHEMBL23584789 | 0.81 | — | — | |
| SCHEMBL23584487 | 0.81 | — | — | |
| SCHEMBL23584485 | 0.81 | BRD4 (0.33) | — | |
| SCHEMBL23584737 | 0.78 | CNR2 (0.38) | — | |
| SCHEMBL19344067 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |