Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18571687 | 1.00 | CYP2A6 (0.37) | CYP2A6TP53SMN1; SMN2 | |
| SCHEMBL19344220 | 0.82 | CYP2A6 (0.39) | CYP2A6 | |
| SCHEMBL18667150 | 0.82 | CYP2A6 (0.39) | CYP2A6 | |
| SCHEMBL4970560 | 0.82 | CYP2A6 (0.39) | CYP2A6 | |
| SCHEMBL19343962 | 0.82 | CYP2A6 (0.39) | CYP2A6 | |
| SCHEMBL20834954 | 0.81 | MAP4K4 (0.37) | CYP2A6 | |
| SCHEMBL25948690 | 0.80 | HRH4 (0.45) | — | |
| SCHEMBL23584542 | 0.80 | HRH4 (0.45) | — | |
| SCHEMBL23959828 | 0.80 | CYP2A6 (0.38) | CYP2A6 | |
| SCHEMBL23584697 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |