Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.30 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
| ▸ | DRD1 | P21728 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23584542 | 1.00 | HRH4 (0.45) | HRH4HRH3LMNATAAR1HSPA5 | |
| SCHEMBL23584717 | 0.85 | HRH4 (0.47) | HRH4HRH3LMNATAAR1HSPA5 | |
| SCHEMBL20144183 | 0.85 | HRH4 (0.47) | HRH4HRH3LMNATAAR1HSPA5 | |
| SCHEMBL19343957 | 0.83 | PDE4D (0.34) | HRH4HRH3LMNAPDE2ADRD1 | |
| SCHEMBL18571687 | 0.80 | CYP2A6 (0.37) | — | |
| SCHEMBL23584545 | 0.80 | CYP2A6 (0.37) | — | |
| SCHEMBL17106780 | 0.78 | HTR1A (0.41) | PDE2A | |
| SCHEMBL22002160 | 0.78 | HTR1A (0.41) | PDE2A | |
| SCHEMBL29937697 | 0.78 | HTR1A (0.41) | PDE2A | |
| SCHEMBL19343951 | 0.78 | HTR1A (0.41) | PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |