Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 7/20 | 0.52 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.52 |
| ▸ | PDE8B | O95263 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23584504 | 0.91 | PRMT5 (0.51) | PRMT5WDR77PDE8B | |
| SCHEMBL23584580 | 0.90 | PRMT5 (0.44) | PRMT5WDR77 | |
| SCHEMBL19344168 | 0.87 | PRMT5 (0.68) | PRMT5WDR77 | |
| SCHEMBL23584454 | 0.83 | PRMT5 (0.44) | PRMT5WDR77 | |
| SCHEMBL19344117 | 0.81 | PRMT5 (0.78) | PRMT5WDR77 | |
| SCHEMBL23584679 | 0.80 | PRMT5 (0.55) | PRMT5WDR77 | |
| SCHEMBL19343880 | 0.79 | PRMT5 (0.58) | PRMT5WDR77 | |
| SCHEMBL22434996 | 0.79 | PRMT5 (0.56) | PRMT5WDR77 | |
| SCHEMBL23584844 | 0.78 | PRMT5 (0.56) | PRMT5WDR77 | |
| SCHEMBL23892488 | 0.78 | ABL1 (0.41) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |