Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 13/20 | 0.55 |
| ▸ | WDR77 | Q9BQA1 | 12/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19344168 | 0.90 | PRMT5 (0.68) | PRMT5WDR77 | |
| SCHEMBL23584842 | 0.90 | PRMT5 (0.54) | PRMT5WDR77 | |
| SCHEMBL23584454 | 0.88 | PRMT5 (0.44) | PRMT5WDR77 | |
| SCHEMBL23584580 | 0.87 | PRMT5 (0.44) | PRMT5WDR77 | |
| SCHEMBL23584831 | 0.87 | PRMT5 (0.51) | PRMT5WDR77 | |
| SCHEMBL23584633 | 0.86 | PRMT5 (0.44) | PRMT5WDR77 | |
| SCHEMBL23584706 | 0.85 | PRMT5 (0.44) | PRMT5WDR77 | |
| SCHEMBL19344407 | 0.85 | PRMT5 (0.43) | PRMT5WDR77 | |
| SCHEMBL23584770 | 0.84 | PRMT5 (0.43) | PRMT5WDR77 | |
| SCHEMBL19343933 | 0.84 | PRMT5 (0.51) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |