Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 3/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22434835 | 0.90 | PRMT5 (0.51) | PRMT5WDR77 | |
| SCHEMBL23584762 | 0.86 | CNR2 (0.39) | PRMT5 | |
| SCHEMBL23584773 | 0.85 | PRMT5 (0.51) | PRMT5WDR77PIP4K2A | |
| SCHEMBL23584706 | 0.82 | PRMT5 (0.44) | PRMT5WDR77 | |
| SCHEMBL23584523 | 0.79 | PRMT5 (0.65) | PRMT5WDR77 | |
| SCHEMBL19344334 | 0.79 | PRMT5 (0.67) | PRMT5WDR77 | |
| SCHEMBL19344064 | 0.78 | PRMT5 (0.40) | PRMT5WDR77 | |
| SCHEMBL19344479 | 0.78 | PRMT5 (0.44) | PRMT5WDR77 | |
| SCHEMBL23584786 | 0.77 | PRMT5 (0.47) | PRMT5WDR77 | |
| SCHEMBL25046655 | 0.76 | PRMT5 (0.38) | PRMT5WDR77PIP4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |