Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 8/20 | 0.50 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10069646 | 0.68 | FUCA1 (0.33) | — | |
| SCHEMBL24923748 | 0.66 | CHRM2 (0.34) | PRMT5WDR77 | |
| SCHEMBL21146567 | 0.57 | LGALS1 (0.48) | — | |
| SCHEMBL20805367 | 0.57 | LGALS1 (0.48) | — | |
| SCHEMBL21621598 | 0.57 | LGALS1 (0.48) | — | |
| SCHEMBL22174657 | 0.57 | LGALS1 (0.48) | — | |
| SCHEMBL25090768 | 0.57 | LGALS1 (0.48) | — | |
| SCHEMBL23844307 | 0.57 | LGALS1 (0.48) | — | |
| SCHEMBL22330650 | 0.57 | FUCA1 (0.39) | — | |
| SCHEMBL2600086 | 0.57 | LGALS1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |