LGALS1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL176281	0.62	17/20
SCHEMBL177372	0.74	13/20
SCHEMBL1955104	0.78	12/20
SCHEMBL1955106	0.78	12/20
SCHEMBL176329	0.76	12/20
SCHEMBL1424934	0.69	12/20
SCHEMBL1955667	0.69	12/20
SCHEMBL2429950	0.64	10/20
SCHEMBL175953	0.62	10/20
SCHEMBL176296	1.00	9/20
SCHEMBL2430521	1.00	8/20
SCHEMBL2430523	1.00	8/20
SCHEMBL2430341	0.82	8/20
SCHEMBL2430344	0.82	8/20
SCHEMBL2432200	0.74	8/20
SCHEMBL2432203	0.74	8/20
SCHEMBL2434970	0.74	8/20
SCHEMBL2434972	0.74	8/20
SCHEMBL1425152	0.66	8/20
SCHEMBL2430456	0.62	8/20

Clinical trials — most relevant to LGALS1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
PROlectin M, a Nucleocapsid TErminal GaleCTin Antagonist for COVID-19	PHASE3	UNKNOWN
A Phase 2b Study of GCS-100 in Patients With Chronic Kidney Disease Caused by Diabetes	PHASE2	UNKNOWN
A Phase 2a Study of Weekly Doses of GCS-100 in Patients With Chronic Kidney Disease	PHASE2	COMPLETED
A Phase 2 Extension Study of Study GCS-100-CS-4002	PHASE2	COMPLETED
Multiple CAR-T Cell Therapy Targeting AML	PHASE1/PHASE2	RECRUITING
Vitamin D Deficiency Treatment Outcomes After Non-ST-Segment Elevation Myocardial Infarction	PHASE2	UNKNOWN
Effect of Modified Citrus Pectin on PSA Kinetics in Biochemical Relapsed PC With Serial Increases in PSA	PHASE2	COMPLETED
GR-MD-02 Plus Pembrolizumab in Melanoma, Non-small Cell Lung Cancer, and Squamous Cell Head and Neck Cancer Patients	PHASE1	COMPLETED
Universal CAR-T Cells Targeting AML	PHASE1	RECRUITING
A Wearable Device and AI-Supported Diet and Exercise Intervention	nan	RECRUITING
The Diagnostic Value of Serum Oncostatin M and Galactin 3 as Biomarkers in Diagnosis of Ulcerative Colitis Disease	nan	NOT_YET_RECRUITING
The Role of Galectins in the Non-invasive Diagnosis of Endometriosis	nan	UNKNOWN
A Serum Galectin-3 Levels in Placenta Accreta Spectrum Pregnancies	nan	COMPLETED
Galectin-3 for Thromboembolic Formation in Patients With Atrial Fibrillation CHA₂DS₂-VASc Scoring	nan	UNKNOWN
Galectin and Respiratory Weaning	nan	UNKNOWN
Effect of Low-Glycemic Index Mediterranean Diet on AGEs	nan	COMPLETED
Biomarkers for Risk Stratification After STEMI	nan	UNKNOWN
Galectin-3 as a Biomarker in Patients With Chagas Disease	nan	COMPLETED
Urinary G3BP as a Novel Biomarker in Lupus Nephritis	nan	NOT_YET_RECRUITING
Evaluation of Galectin-3 in Serum and Saliva of Pemphigus Patients	nan	UNKNOWN
Galectin-3 Binding Protein in Cardiovascular Disease and Chronic Heart Failure	nan	COMPLETED
Galectin-3 in Septic and Non-septic Acute Kidney Injury	nan	UNKNOWN
Galectin 3 Dosage in Diagnosis of Nodular and Multinodular Goiter	nan	COMPLETED
Serum Galectin-3 as a Marker of Human Papillomavirus Infection	nan	COMPLETED
Testicular Proteins for Sperm Retrieval Prediction Protein1, Testis-Expressed Gene 101, and Lectin Galactoside-binding Protein in Predicting Surgical Sperm Retrieval in Men With Non-Obstructive Azoospermia	nan	UNKNOWN
Evaluation of Serum Galectin-9 Level in Systemic Lupus Erythematosus Patients and it's Association With Disease Activity and Organ Damage	nan	UNKNOWN
Association Between Galectin-3 Levels and Outcomes in Patients With Renal Cell Carcinoma, Transitional Cell Carcinoma , Non Small Cell Lung Cancer, and Hepatocellular Carcinoma, Treated With PD-1/PDL-1 Inhibitors	nan	RECRUITING
Measuring Immune Tolerance to Predict Miscarriage or Failed Embryo Transfer	nan	COMPLETED
Galectin-3 in Patients With Endometriosis	nan	UNKNOWN
GCF Galectin-3 and Interleukin-1beta Levels in Periodontitis.	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a LGALS1 binder may also engage these)

Protein	Name	Similarity
C0HJR3	—	0.998	C0HJR3 →
C0HJQ1	—	0.996	C0HJQ1 →
Q5R7M1	—	0.994	Q5R7M1 →
P48538	—	0.993	P48538 →
P81184	—	0.993	P81184 →
Q49I35	—	0.993	Q49I35 →
P11116	—	0.992	P11116 →
P11762	—	0.991	P11762 →
P16045	—	0.990	P16045 →
LGALS2	Galectin-2	0.972	landscape →
P07583	—	0.968	P07583 →
Q9Z144	—	0.964	Q9Z144 →
P97590	—	0.964	P97590 →
Q9CQW5	—	0.961	Q9CQW5 →
LGALS8	Galectin-8	0.958	landscape →
Q9JL15	—	0.956	Q9JL15 →
O54974	—	0.952	O54974 →
Q62665	—	0.952	Q62665 →
O54891	—	0.952	O54891 →
P23668	—	0.952	P23668 →
P47967	—	0.950	P47967 →
Q3B8N2	—	0.949	Q3B8N2 →
P97840	—	0.948	P97840 →
Q6DKI2	—	0.948	Q6DKI2 →
Q29058	—	0.947	Q29058 →
LGALS9	Galectin-9	0.944	landscape →
P56217	—	0.944	P56217 →
Q9UHV8	—	0.942	Q9UHV8 →
LGALS4	Galectin-4	0.941	landscape →
Q8K419	—	0.940	Q8K419 →