Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLRMT | O00411 | 1/20 | 0.33 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.31 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19344174 | 0.83 | POLRMT (0.32) | POLRMTMBOAT4DPP4DPP8DPP9 | |
| SCHEMBL13696066 | 0.79 | DOT1L (0.37) | POLRMTDOT1L | |
| SCHEMBL13532219 | 0.79 | DOT1L (0.37) | POLRMTDOT1L | |
| SCHEMBL20058766 | 0.79 | DOT1L (0.37) | POLRMTDOT1L | |
| SCHEMBL23584490 | 0.73 | — | — | |
| SCHEMBL22435122 | 0.73 | POLRMT (0.34) | POLRMT | |
| SCHEMBL19344308 | 0.73 | POLRMT (0.34) | POLRMT | |
| SCHEMBL9912317 | 0.72 | DOT1L (0.35) | POLRMTDOT1L | |
| SCHEMBL18666890 | 0.72 | HSPA5 (0.36) | POLRMTDOT1L | |
| SCHEMBL13696400 | 0.72 | DOT1L (0.35) | POLRMTDOT1L |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |