Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 3/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | POLRMT | O00411 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19344147 | 0.92 | PRMT5 (0.36) | PRMT5POLRMT | |
| SCHEMBL22434949 | 0.90 | PRMT5 (0.34) | PRMT5 | |
| SCHEMBL19344200 | 0.86 | PRMT5 (0.48) | PRMT5WDR77POLRMT | |
| SCHEMBL19343998 | 0.85 | PRMT5 (0.35) | PRMT5 | |
| SCHEMBL19343992 | 0.85 | PRMT5 (0.35) | PRMT5 | |
| SCHEMBL19344235 | 0.82 | PRMT5 (0.38) | PRMT5WDR77POLRMT | |
| SCHEMBL23584767 | 0.81 | PRMT5 (0.37) | PRMT5WDR77POLRMT | |
| SCHEMBL22434945 | 0.81 | PRMT5 (0.38) | PRMT5WDR77POLRMT | |
| SCHEMBL22435031 | 0.81 | PRMT5 (0.36) | PRMT5WDR77 | |
| SCHEMBL19344194 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |