⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22435096 | 0.91 | — | — | |
| SCHEMBL23584783 | 0.86 | — | — | |
| SCHEMBL19344138 | 0.85 | POLRMT (0.34) | — | |
| SCHEMBL23584820 | 0.85 | CSNK2A2 (0.32) | — | |
| SCHEMBL19344282 | 0.82 | POLRMT (0.30) | — | |
| SCHEMBL19344170 | 0.81 | POLRMT (0.30) | — | |
| SCHEMBL19344137 | 0.80 | POLRMT (0.34) | — | |
| SCHEMBL19343958 | 0.80 | CSNK2A2 (0.32) | — | |
| SCHEMBL23584787 | 0.80 | PRMT5 (0.38) | — | |
| SCHEMBL19344087 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017153186-A1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-14 | — | — | WO | disclosed |