Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 14/20 | 0.50 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | METTL3 | Q86U44 | 3/20 | 0.34 |
| ▸ | ADK | P55263 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23584878 | 0.89 | PRMT5 (0.51) | PRMT5WDR77KCNH2GRIN2BMETTL3 | |
| SCHEMBL23584872 | 0.88 | PRMT5 (0.52) | PRMT5WDR77METTL3ADKMEN1 | |
| SCHEMBL23584539 | 0.87 | PRMT5 (0.54) | PRMT5WDR77METTL3ADKMEN1 | |
| SCHEMBL19344226 | 0.87 | PRMT5 (0.55) | PRMT5WDR77METTL3ADKMEN1 | |
| SCHEMBL19344316 | 0.84 | PRMT5 (0.72) | PRMT5WDR77METTL3ADK | |
| SCHEMBL23584838 | 0.83 | PRMT5 (0.70) | PRMT5WDR77METTL3ADKMEN1 | |
| SCHEMBL23584805 | 0.81 | PRMT5 (0.51) | PRMT5WDR77METTL3ADKMEN1 | |
| SCHEMBL23584865 | 0.79 | PRMT5 (0.40) | PRMT5WDR77 | |
| SCHEMBL23584544 | 0.79 | PRMT5 (0.50) | PRMT5WDR77METTL3MEN1 | |
| SCHEMBL23584613 | 0.79 | PRMT5 (0.50) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |