Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 7/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19344219 | 0.81 | PRMT5 (0.41) | PRMT5WDR77 | |
| SCHEMBL23584460 | 0.81 | PRMT5 (0.42) | PRMT5WDR77 | |
| SCHEMBL23584706 | 0.80 | PRMT5 (0.44) | PRMT5WDR77 | |
| SCHEMBL23584539 | 0.80 | PRMT5 (0.54) | PRMT5WDR77 | |
| SCHEMBL19344226 | 0.79 | PRMT5 (0.55) | PRMT5WDR77 | |
| SCHEMBL23584872 | 0.79 | PRMT5 (0.52) | PRMT5WDR77 | |
| SCHEMBL23584855 | 0.79 | PRMT5 (0.50) | PRMT5WDR77 | |
| SCHEMBL19344479 | 0.76 | PRMT5 (0.44) | PRMT5WDR77 | |
| SCHEMBL19343930 | 0.75 | PRMT5 (0.40) | PRMT5WDR77 | |
| SCHEMBL23584710 | 0.74 | PRMT5 (0.44) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |