Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15658536 | 0.81 | PDE4B (0.47) | PDE4BPDE4DKDM4EALDH1A1HPGD | |
| SCHEMBL15660694 | 0.78 | PDE4B (0.54) | PDE4BPDE4DKDM4EALDH1A1HPGD | |
| SCHEMBL23612641 | 0.74 | PDE4B (0.51) | PDE4BPDE4DKDM4E | |
| SCHEMBL5957185 | 0.66 | PDE4B (0.51) | PDE4BPDE4DKDM4EALDH1A1HPGD | |
| SCHEMBL24725826 | 0.65 | PDE4B (0.71) | PDE4BPDE4D | |
| SCHEMBL5957254 | 0.65 | PDE4B (0.42) | PDE4BPDE4DKDM4E | |
| SCHEMBL15661807 | 0.65 | PDE4B (0.56) | PDE4BPDE4DKDM4EALDH1A1HPGD | |
| SCHEMBL5957225 | 0.64 | PDE4B (0.44) | PDE4BPDE4DALDH1A1HPGDL3MBTL1 | |
| SCHEMBL15947929 | 0.64 | PDE4B (0.41) | PDE4BPDE4DALDH1A1L3MBTL1 | |
| SCHEMBL15660097 | 0.64 | PDE4B (0.70) | PDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3842420-B1 | HETEROARYL INHIBITORS OF PDE4 | TETRA DISCOVERY PARTNERS LLC (US) | 2022-12-07 | — | — | EP | disclosed |
| EP-3842420-A1 | HETEROARYL INHIBITORS OF PDE4 | Tetra Discovery Partners LLC (US) | 2021-06-30 | — | — | EP | disclosed |