Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 13/20 | 0.42 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | TEK | Q02763 | 1/20 | 0.41 |
| ▸ | MELK | Q14680 | 1/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2234548 | 0.87 | KMT2A (0.51) | BRAFIRAK4RAF1NPC1RAB9A | |
| SCHEMBL2364955 | 0.79 | CSF1R (0.47) | BRAFERN1RAF1CYP2C9CSF1R | |
| SCHEMBL2364506 | 0.77 | CSF1R (0.47) | BRAFERN1RAF1CYP2C9RAB9A | |
| SCHEMBL2364951 | 0.77 | BRAF (0.44) | BRAFERN1RAF1CYP2C9CSF1R | |
| SCHEMBL2233027 | 0.72 | BRAF (0.55) | BRAFIRAK4RAF1CSF1RDDR2 | |
| SCHEMBL19073445 | 0.72 | CSF1R (0.52) | BRAFIRAK4RAF1CSF1RDDR2 | |
| SCHEMBL14137176 | 0.71 | CSF1R (0.51) | BRAFIRAK4RAF1CSF1RDDR2 | |
| SCHEMBL2237093 | 0.70 | ERN1 (0.54) | BRAFERN1RAF1CYP2C9CSF1R | |
| SCHEMBL2237783 | 0.70 | BRAF (0.54) | BRAFERN1RAF1CYP2C9RAB9A | |
| SCHEMBL31219997 | 0.70 | SMN1; SMN2 (0.53) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2528925-A2 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES | Hanmi Science Co., Ltd. (KR) | 2012-12-05 | — | — | EP | disclosed |
| WO-2011093684-A2 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES | HANMI HOLDINGS CO., LTD. (KR) | 2011-08-04 | — | — | WO | disclosed |