Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 9/20 | 0.42 |
| ▸ | PTPRC | P08575 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 6/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | DDR2 | Q16832 | 5/20 | 0.40 |
| ▸ | DDR1 | Q08345 | 4/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | TEK | Q02763 | 1/20 | 0.40 |
| ▸ | MELK | Q14680 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2312969 | 0.88 | RAF1 (0.48) | BRAFPTGS1CSF1RAURKARAF1 | |
| SCHEMBL2364955 | 0.86 | CSF1R (0.47) | BRAFERN1CSF1RRAF1CYP2C9 | |
| SCHEMBL2364506 | 0.82 | CSF1R (0.47) | BRAFERN1CSF1RRAF1CYP2C9 | |
| SCHEMBL2233855 | 0.77 | GRM4 (0.54) | BRAFERN1CSF1RRAF1CYP2C9 | |
| SCHEMBL2359166 | 0.77 | BRAF (0.46) | BRAFERN1CSF1RRAF1CYP2C9 | |
| SCHEMBL12433866 | 0.75 | CSF1R (0.53) | BRAFCSF1RRAF1DDR2DDR1 | |
| SCHEMBL2314140 | 0.75 | CSF1R (0.52) | BRAFCSF1RAURKARAF1DDR2 | |
| SCHEMBL2356829 | 0.74 | RAF1 (0.52) | BRAFERN1CSF1RRAF1DDR2 | |
| SCHEMBL2313222 | 0.74 | CSF1R (0.66) | BRAFCSF1RRAF1CYP2C9DDR2 | |
| SCHEMBL2310995 | 0.74 | BRAF (0.54) | BRAFCSF1RAURKARAF1DDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2528925-A2 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES | Hanmi Science Co., Ltd. (KR) | 2012-12-05 | — | — | EP | disclosed |
| WO-2011093684-A2 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES | HANMI HOLDINGS CO., LTD. (KR) | 2011-08-04 | — | — | WO | disclosed |