Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 11/20 | 0.35 |
| ▸ | PPARD | Q03181 | 11/20 | 0.35 |
| ▸ | PPARA | Q07869 | 11/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2315677 | 0.94 | MAPK14 (0.34) | MAPK14GCGRJMJD6CETPKDM4E | |
| SCHEMBL2316266 | 0.90 | MAPK14 (0.33) | MAPK14GCGRJMJD6CETPKDM4E | |
| SCHEMBL2316004 | 0.90 | CETP (0.40) | MAPK14GCGRJMJD6PPARGPPARD | |
| SCHEMBL17836539 | 0.88 | MAPK14 (0.34) | MAPK14PPARGPPARDPPARA | |
| SCHEMBL17836529 | 0.88 | PPARG (0.35) | MAPK14PPARGPPARDPPARA | |
| SCHEMBL2317760 | 0.86 | MAPK14 (0.34) | MAPK14PPARGPPARDPPARA | |
| SCHEMBL2316779 | 0.85 | MAPK14 (0.34) | MAPK14PPARGPPARDPPARAMAPK1 | |
| SCHEMBL2316110 | 0.85 | PPARG (0.35) | MAPK14PPARGPPARDPPARA | |
| SCHEMBL2364647 | 0.84 | PPARG (0.36) | MAPK14PPARGPPARDPPARAMAPK1 | |
| SCHEMBL14108523 | 0.84 | MAPK14 (0.35) | MAPK14PPARGPPARDPPARAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2528909-A1 | SULFONAMIDO DERIVATIVES OF 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2012-12-05 | — | — | EP | claimed |
| WO-2011092088-A1 | SULFONAMIDO DERIVATIVES OF 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-08-04 | — | — | WO | claimed |
| EP-2528909-A1 | SULFONAMIDO DERIVATIVES OF 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2012-12-05 | — | — | EP | disclosed |
| WO-2011092088-A1 | SULFONAMIDO DERIVATIVES OF 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-08-04 | — | — | WO | disclosed |