Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | PDE2A | O00408 | 2/20 | 0.47 |
| ▸ | BCDIN3D | Q7Z5W3 | 8/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30034770 | 1.00 | HTR2C (0.54) | HTR2CPIK3CAPDE5ACA12CA1 | |
| SCHEMBL23579669 | 0.90 | HTR2C (0.53) | HTR2CPDE5APDE2ABCDIN3D | |
| SCHEMBL30033897 | 0.90 | HTR2C (0.53) | HTR2CPIK3CACA1CA2CA9 | |
| SCHEMBL30034965 | 0.90 | HTR2C (0.53) | HTR2CPDE5APDE2ABCDIN3D | |
| SCHEMBL23579785 | 0.90 | HTR2C (0.53) | HTR2CPIK3CACA1CA2CA9 | |
| SCHEMBL13944721 | 0.85 | HTR2C (0.74) | HTR2CPIK3CAPDE5APDE2AKDM4E | |
| SCHEMBL13943315 | 0.83 | PIK3CA (0.63) | HTR2CPIK3CAPDE5APDE2ABCDIN3D | |
| SCHEMBL23599123 | 0.83 | PIK3CB (0.48) | PIK3CACA12CA1CA2CA9 | |
| SCHEMBL30033416 | 0.83 | PIK3CB (0.48) | PIK3CACA12CA1CA2CA9 | |
| SCHEMBL31337095 | 0.81 | PDE2A (0.55) | HTR2CCA1CA2CA9PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115151550-A | Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP 1) modulators and uses thereof | 桑福德·伯纳姆·普雷比医学发现研究所 | 2022-10-04 | — | — | CN | disclosed |
| WO-2021133915-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) MODULATORS AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-07-01 | — | — | WO | disclosed |