SCHEMBL23601421

SCHEMBL23601421

CN(c1cccc(-c2ccc(C(C)(C)C)cc2Cl)c1)c1nc2nncn2c2cc(Cl)ccc12

nearest known ligand 0.39

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
FNTA P49354 5/20 0.39
FNTB P49356 5/20 0.39
CNR1 P21554 1/20 0.32
CNR2 P34972 1/20 0.32
PTAFR P25105 1/20 0.32
TP53 P04637 1/20 0.31
MAPT P10636 1/20 0.31
MAT2A P31153 4/20 0.30
PRMT5 O14744 2/20 0.30
CYP1A2 P05177 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29909732 0.93 FNTA (0.39) FNTAFNTBCNR1CNR2PTAFR
SCHEMBL23576841 0.93 FNTA (0.39) FNTAFNTBCNR1CNR2PTAFR
SCHEMBL29909526 0.90 FNTA (0.39) FNTAFNTBTP53MAPTMAT2A
SCHEMBL23577383 0.90 FNTA (0.39) FNTAFNTBTP53MAPTMAT2A
SCHEMBL23577059 0.89 FNTA (0.41) FNTAFNTBCNR1CNR2PTAFR
SCHEMBL29909922 0.89 FNTA (0.41) FNTAFNTBCNR1CNR2PTAFR
SCHEMBL23600551 0.85 FNTA (0.40) FNTAFNTBTP53MAPTMAT2A
SCHEMBL23601743 0.85 FNTA (0.39) FNTAFNTBTP53MAPTMAT2A
SCHEMBL23577102 0.84 FNTA (0.41) FNTAFNTBTP53MAPTMAT2A
SCHEMBL23600548 0.84 FNTA (0.40) FNTAFNTBTP53MAPTMAT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4081305-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS Carna Biosciences, Inc. (JP) 2022-11-02 EP disclosed
US-20220324866-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS GILEAD SCIENCES, INC. 2022-10-13 US disclosed
WO-2021130638-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS CARNA BIOSCIENCES, INC. (JP) 2021-07-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220324866-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS DGKG, DGKB, DGKK FNTA 968/4885FNTB 743/4885CNR1 1391/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.