DGKB — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL21830991	1.00	2/20
SCHEMBL29654799	1.00	2/20
SCHEMBL23293507	0.87	2/20
SCHEMBL23293148	0.84	2/20
SCHEMBL23293265	0.84	2/20
SCHEMBL23293307	0.84	2/20
SCHEMBL23293196	0.83	2/20
SCHEMBL23293138	0.83	2/20
SCHEMBL23293147	0.81	2/20
SCHEMBL23293186	0.81	2/20
SCHEMBL23293506	0.81	2/20
SCHEMBL23293193	0.79	2/20
SCHEMBL23293351	0.79	2/20
SCHEMBL23293353	0.79	2/20
SCHEMBL23293169	0.78	2/20
SCHEMBL23293415	0.78	2/20
SCHEMBL23293349	0.76	2/20
SCHEMBL23293461	0.76	2/20
SCHEMBL23293182	0.76	2/20
SCHEMBL23293369	0.76	2/20

Clinical trials — most relevant to DGKB by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity	PHASE4	COMPLETED
Mitochondrial Oxidation and Insulin Resistance in Burn Patients Treated With Fenofibrate	PHASE2/PHASE3	WITHDRAWN
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus	PHASE3	UNKNOWN
HP-211 Safety and Proof of Concept Dose Ranging Study in Patients With Type 2 Diabetes	PHASE2	RECRUITING
Vitamin E and DHA-EE on NAFLD - Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial (PUVENAFLD)	PHASE2	COMPLETED
Vascular Protective Effect of Rosuvastatin in Arteriovenous Fistula	PHASE2	COMPLETED
Acute Effect of HP-211 (Axulin) on Blood Glucose and Serum Insulin Responses in Healthy Lean and Overweight Humans	PHASE1	COMPLETED
Duality of Lipids: the Athlete's Paradox	nan	COMPLETED
Free Fatty Acid Induced Insulin Resistance	nan	COMPLETED
Skeletal Muscle Diacylglycerol and Sphingolipids - Impact of Localization and Species on Insulin Resistance in Humans	nan	COMPLETED
Tissue Lipids and Insulin Resistance	nan	WITHDRAWN
The Role of Arachidonic Acid Metabolites, From Patients With Metabolic Syndrome	nan	UNKNOWN
Study of Changes in Skeletal Muscle After Caloric Restriction	nan	ACTIVE_NOT_RECRUITING
Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in PAH	nan	COMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
A Case Control Study of Resveratrol Effects in Coronary Artery Disease Patients With Metabolic Syndrome	nan	COMPLETED
Oxidative Stress in Intestinal Metaplasia and Metabolic Syndrome	nan	UNKNOWN
Sleep Restriction and Postprandial Lipemia	nan	COMPLETED
Effects of Fish Oils on Inflammation and Insulin Resistance	nan	COMPLETED
The Study Aims to Investigate the Effects of Oral Inositols on Insulin-resistance in Children With Obesity.	nan	UNKNOWN
Extracellular Vesicles, Insulin Action, and Exercise	nan	RECRUITING
The Effect Of DAAs on miRNA-122 And Insulin Resistance In Chronic HCV Patients	nan	UNKNOWN
A 12 Week, 3-Period Study to Evaluate the Effects of a Dietary Supplement on Lipid Metabolism	nan	COMPLETED
Genetic and Environmental Determinants of Triglycerides (GOLDN)	nan	COMPLETED
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity.	nan	COMPLETED
Effect of Short-Term Exercise Training on ATP Synthesis in Relatives of Type 2 Diabetic Humans	nan	COMPLETED
Effect of Age on Glucose and Lipid Metabolism	nan	COMPLETED
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Role of Dairy Products in Weight Maintenance	nan	COMPLETED
p-AKT Expression on Clinical Outcomes in Malignant Lymphoma	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a DGKB binder may also engage these)

Protein	Name	Similarity
DGKG	Diacylglycerol kinase gamma	1.000	landscape →
Q6NS52	—	1.000	Q6NS52 →
DGKA	Diacylglycerol kinase alpha	0.998	landscape →
Q03603	—	0.998	Q03603 →
P20192	—	0.998	P20192 →
P49621	—	0.997	P49621 →
P49620	—	0.996	P49620 →
P51556	—	0.996	P51556 →
Q91WG7	—	0.994	Q91WG7 →
O88673	—	0.994	O88673 →
A0JN54	—	0.991	A0JN54 →
Q2KHP8	—	0.991	Q2KHP8 →
Q6DNF3	—	0.991	Q6DNF3 →
Q582G4	—	0.991	Q582G4 →
O76373	—	0.991	O76373 →
Q9D1P2	—	0.991	Q9D1P2 →
Q09178	—	0.990	Q09178 →
Q39017	—	0.990	Q39017 →
Q8LI34	—	0.990	Q8LI34 →
A3QM97	—	0.990	A3QM97 →
Q5JTY5	—	0.989	Q5JTY5 →
Q7ZY18	—	0.989	Q7ZY18 →
G5EEM9	—	0.989	G5EEM9 →
Q12756	—	0.989	Q12756 →
Q9FFN7	—	0.989	Q9FFN7 →
P19334	—	0.989	P19334 →
Q5FWY4	—	0.989	Q5FWY4 →
Q9EQW7	—	0.989	Q9EQW7 →
SEPTIN8	Septin-8	0.989	landscape →
Q86C56	—	0.989	Q86C56 →