SCHEMBL23601752

SCHEMBL23601752

FC(F)(F)CN(c1cccc(CCC2(C(F)(F)F)CC2)c1)c1nc2nncn2c2cc(Cl)ccc12

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.32
MAPT P10636 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23601777 0.90 TP53 (0.32) TP53MAPT
SCHEMBL23601675 0.81 MAT2A (0.38) TP53MAPT
SCHEMBL23576759 0.80
SCHEMBL23601381 0.80
SCHEMBL23577396 0.78 TP53 (0.30) TP53MAPT
SCHEMBL23601581 0.77
SCHEMBL23601542 0.75
SCHEMBL23577043 0.73 FNTA (0.31)
SCHEMBL23601234 0.73 SMN1; SMN2 (0.33) TP53MAPT
SCHEMBL29909179 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021130638-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS CARNA BIOSCIENCES, INC. (JP) 2021-07-01 WO disclosed