Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.51 |
| ▸ | TDO2 | P48775 | 2/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2360375 | 0.79 | IDO1 (0.54) | IDO1TDO2FAAHMGLLSMN1; SMN2 | |
| SCHEMBL13438861 | 0.79 | SMN1; SMN2 (0.58) | IDO1TDO2FAAHMGLLSMN1; SMN2 | |
| SCHEMBL2360281 | 0.76 | IDO1 (0.51) | IDO1TDO2FAAHMGLLSMN1; SMN2 | |
| SCHEMBL2360376 | 0.75 | IDO1 (0.52) | IDO1TDO2FAAHMGLLSMN1; SMN2 | |
| SCHEMBL2359577 | 0.74 | IDO1 (0.53) | IDO1TDO2FAAHMGLLSMN1; SMN2 | |
| SCHEMBL2324066 | 0.74 | NOTUM (0.60) | IDO1TDO2FAAHMGLLSMN1; SMN2 | |
| SCHEMBL14234095 | 0.73 | ALDH1A1 (0.62) | MGLLSMN1; SMN2LMNAALDH1A1HPGD | |
| SCHEMBL2360734 | 0.73 | IDO1 (0.52) | IDO1TDO2FAAHMGLLSMN1; SMN2 | |
| SCHEMBL2359408 | 0.72 | KMT2A (0.49) | IDO1TDO2FAAHMGLLSMN1; SMN2 | |
| SCHEMBL13657383 | 0.72 | SMN1; SMN2 (0.56) | IDO1TDO2FAAHMGLLSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2356113-B1 | HETEROCYCLICALLY SUBSTITUTED ARYL COMPOUNDS AS HIF INHIBITORS | BAYER IP GMBH (DE) | 2015-01-07 | — | — | EP | disclosed |
| EP-2356113-A1 | HETEROCYCLICALLY SUBSTITUTED ARYL COMPOUNDS AS HIF INHIBITORS | Bayer Schering Pharma Aktiengesellschaft (DE) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010054763-A1 | HETEROCYCLICALLY SUBSTITUTED ARYL COMPOUNDS AS HIF INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-05-20 | — | — | WO | disclosed |