SCHEMBL23604396

SCHEMBL23604396

Cc1ccc(N)c(Cl)c1Br

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 9/20 0.43
ALDH1A1 P00352 9/20 0.41
TDP1 Q9NUW8 7/20 0.41
TSHR P16473 4/20 0.41
CASP1 P29466 1/20 0.36
CD44 P16070 1/20 0.36
THRB P10828 2/20 0.35
MEN1 O00255 1/20 0.35
NPC1 O15118 1/20 0.35
POLB P06746 1/20 0.35
MAPT P10636 1/20 0.35
APEX1 P27695 1/20 0.35
RECQL P46063 1/20 0.35
RAB9A P51151 1/20 0.35
BLM P54132 1/20 0.35
KMT2A Q03164 1/20 0.35
MCL1 Q07820 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
MAPK1 P28482 1/20 0.35
ALOX15 P16050 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6582691 0.81 CYP3A4 (0.43) CYP3A4ALDH1A1TDP1TSHRCASP1
SCHEMBL3884369 0.79 CYP3A4 (0.50) CYP3A4ALDH1A1TDP1TSHRCASP1
SCHEMBL10798531 0.77 CYP3A4 (0.46) CYP3A4ALDH1A1TDP1TSHRCASP1
SCHEMBL526351 0.76 ALDH1A1 (0.50) CYP3A4ALDH1A1TDP1TSHRCASP1
SCHEMBL11026968 0.75 TSHR (0.39) CYP3A4ALDH1A1TDP1TSHRCASP1
SCHEMBL28678653 0.75 CYP3A4 (0.46) CYP3A4ALDH1A1TDP1TSHRCASP1
SCHEMBL19830027 0.75 CYP3A4 (0.36) CYP3A4ALDH1A1MAPK1
SCHEMBL31107290 0.75 ALDH1A1 (0.44) CYP3A4ALDH1A1TDP1TSHRCASP1
SCHEMBL6403160 0.75 CYP3A4 (0.46) CYP3A4ALDH1A1TDP1TSHRCASP1
SCHEMBL29566675 0.75 ALDH1A1 (0.44) CYP3A4ALDH1A1TDP1TSHRCASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4083032-A1 PD-L1 ANTAGONIST COMPOUND Adlai Nortye Biopharma Co., Ltd. (CN) 2022-11-02 EP disclosed
WO-2021129584-A1 PD-L1 ANTAGONIST COMPOUND 杭州阿诺生物医药科技有限公司 2021-07-01 WO disclosed