Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | PGK1 | P00558 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21885794 | 0.82 | S1PR2 (0.32) | LMNAALDH1A1MAPTNFKB1NFKB2 | |
| SCHEMBL27238732 | 0.79 | KMT2A (0.42) | CA1CA2CA9LMNANPC1 | |
| SCHEMBL9995068 | 0.77 | PTK2 (0.49) | DYRK1AL3MBTL1PTK2LMNAALDH1A1 | |
| SCHEMBL21827717 | 0.74 | KLK7 (0.50) | KDM4EHSD17B10NPSR1ALDH1A1NPC1 | |
| SCHEMBL2489789 | 0.70 | ALDH1A1 (0.42) | L3MBTL1PTK2CA1CA2CA9 | |
| SCHEMBL28968518 | 0.69 | ALDH1A1 (0.46) | PTK2CA1CA2CA9RXFP1 | |
| SCHEMBL11637557 | 0.69 | MAPT (0.51) | DYRK1AL3MBTL1PTK2LMNANPSR1 | |
| SCHEMBL26694673 | 0.69 | ALDH1A1 (0.42) | DYRK1AL3MBTL1KDM4ENPSR1ALDH1A1 | |
| SCHEMBL23994067 | 0.68 | MEN1 (0.33) | NPC1RAB9A | |
| SCHEMBL28947340 | 0.68 | MEN1 (0.33) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021133917-A1 | SMARCA INHIBITORS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-07-01 | — | — | WO | disclosed |