SCHEMBL2360955

SCHEMBL2360955

CCCCC[CH][Si](OC)(OC)OC

nearest known ligand 0.39

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.39
FAAH O00519 3/20 0.34
TRPV1 Q8NER1 1/20 0.34
THRB P10828 1/20 0.33
LMNA P02545 1/20 0.32
ALDH1A1 P00352 2/20 0.32
DNM1 Q05193 3/20 0.32
MEN1 O00255 1/20 0.32
MAPT P10636 1/20 0.32
PLA2G4A P47712 1/20 0.32
PAFAH1B2 P68402 1/20 0.32
KMT2A Q03164 1/20 0.32
MGLL Q99685 1/20 0.32
ABHD6 Q9BV23 1/20 0.32
LPAR3 Q9UBY5 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8332265 0.98 TSHR (0.42) TSHRFAAHTRPV1THRBLMNA
SCHEMBL23248772 0.98 TSHR (0.42) TSHRFAAHTRPV1THRBLMNA
SCHEMBL8330790 0.98 TSHR (0.42) TSHRFAAHTRPV1THRBLMNA
SCHEMBL2361174 0.92 TSHR (0.38) TSHRLMNAALDH1A1
SCHEMBL6783239 0.87 TSHR (0.33) TSHRFAAHTRPV1LPAR3
SCHEMBL6787500 0.87 TSHR (0.33) TSHRFAAHTRPV1LPAR3
SCHEMBL2137716 0.81 TSHR (0.32) TSHRALDH1A1
SCHEMBL6785024 0.79 TSHR (0.32) TSHRALDH1A1
SCHEMBL2361158 0.78 TSHR (0.37) TSHRFAAHTRPV1THRBALDH1A1
SCHEMBL2361315 0.78 TSHR (0.37) TSHRFAAHTRPV1THRBLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2231740-B1 MOISTURE-CURABLE SILYLATED POLYUREA AND ADHESIVE, SEALANT AND COATING COMPOSITIONS CONTAINING SAME MOMENTIVE PERFORMANCE MAT INC (US) 2011-08-24 EP claimed
US-6013724-A TETRAMETHOXYSILANE PARTIAL HYDROLYZED CONDENSATE HAVING A SPECIFIC SILANOL-METHOXYSILYL GROUP MOLAR RATIO AND CONDENSATION OF TETRAMETHOXYSILANE AND A FILM-FORMING RESIN AND/OR INORGANIC BINDER HAVING ALKOXYSILYL AS CURING GROUP NIPPON PAINT CO., LTD. (JP) 2000-01-11 US claimed
EP-0863191-A2 Raindrop fouling-resistant paint film, coating composition, film-forming method, and coated article Nippon Paint Co., Ltd. (JP) 1998-09-09 EP claimed
WO-2024106213-A1 METHOD FOR PRODUCING DISILOXANE COMPOUND 信越化学工業株式会社 2024-05-23 WO disclosed
EP-3688111-A1 THERMALLY CONDUCTIVE COMPOSITION Dow Silicones Corporation (US) 2020-08-05 EP disclosed
WO-2019061288-A1 THERMALLY CONDUCTIVE COMPOSITION DOW SILICONES CORPORATION (US) 2019-04-04 WO disclosed
US-20040259992-A1 Two-component adhesion promoter combination of an unsaturated alkoxysilane and a mercaptoalkyl alkoxysilane, for use in dental prostheses 3M ESPE AG (DE) 2004-12-23 US disclosed
US-6013724-A TETRAMETHOXYSILANE PARTIAL HYDROLYZED CONDENSATE HAVING A SPECIFIC SILANOL-METHOXYSILYL GROUP MOLAR RATIO AND CONDENSATION OF TETRAMETHOXYSILANE AND A FILM-FORMING RESIN AND/OR INORGANIC BINDER HAVING ALKOXYSILYL AS CURING GROUP NIPPON PAINT CO., LTD. (JP) 2000-01-11 US disclosed
EP-0863191-A2 Raindrop fouling-resistant paint film, coating composition, film-forming method, and coated article Nippon Paint Co., Ltd. (JP) 1998-09-09 EP disclosed
US-5780530-A COMPRISING POLYOL RESIN, CURING AGENT, REACTIVE ULTRAFINE SILICA PARTICLES, CATALYST NIPPON PAINT CO., LTD. (JP) 1998-07-14 US disclosed
EP-0796904-A2 Thermosetting resin composition NIPPON PAINT CO., LTD. (JP) 1997-09-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040259992-A1 Two-component adhesion promoter combination of an unsaturated alkoxysilane and a mercaptoalkyl alkoxysilane, for use in dental prostheses ITGA2, ITGB2, ITGA2B TSHR 3882/4885FAAH 3731/4885TRPV1 2167/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.