Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23610585 | 1.00 | TSHR (0.46) | TSHRSTSNPC1RAB9ACASP3 | |
| SCHEMBL6649922 | 0.80 | STS (0.54) | TSHRSTSNPC1RAB9ACASP3 | |
| SCHEMBL21711526 | 0.78 | TSHR (0.42) | TSHRNPC1RAB9ACASP3SMN1; SMN2 | |
| SCHEMBL786065 | 0.71 | TSHR (0.53) | TSHRSTSNPC1RAB9ACASP3 | |
| SCHEMBL30387165 | 0.71 | TSHR (0.53) | TSHRSTSNPC1RAB9ACASP3 | |
| SCHEMBL29501133 | 0.70 | TSHR (0.45) | TSHRNPC1RAB9ACASP3SMN1; SMN2 | |
| SCHEMBL15638307 | 0.70 | TSHR (0.60) | TSHRNPC1RAB9ACASP3SMN1; SMN2 | |
| SCHEMBL15704079 | 0.70 | TRPA1 (0.37) | SMN1; SMN2TRPA1 | |
| SCHEMBL15704081 | 0.70 | TRPA1 (0.37) | SMN1; SMN2TRPA1 | |
| SCHEMBL29501123 | 0.69 | TSHR (0.42) | TSHRNPC1RAB9ACASP3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11702412-B2 | Bicyclic [4,6,0] hydroxamic acids as HDAC inhibitors | VALO HEALTH, INC. (US) | 2023-07-18 | — | — | US | disclosed |
| US-20210206755-A1 | BICYCLIC [4,6,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS | VALO HEALTH, INC. | 2021-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11702412-B2 | Bicyclic [4,6,0] hydroxamic acids as HDAC inhibitors | HDAC1, HDAC2, HDAC4 | TSHR 3169/4885STS 1733/4885NPC1 2084/4885 |
| US-20210206755-A1 | BICYCLIC [4,6,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS | HDAC1, HDAC2, HDAC4 | TSHR 3169/4885STS 1733/4885NPC1 2084/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.