SCHEMBL23612013

SCHEMBL23612013

COC(=O)c1cc(OC)c(C2CCC(F)(F)CC2)cn1.COc1cc(C(=O)O)ncc1C1CCC(F)(F)CC1

nearest known ligand 0.44

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TRPC6 Q9Y210 16/20 0.43
CNR2 P34972 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23612054 0.95 TRPC6 (0.46) TRPC6CNR2
SCHEMBL30021227 0.95 TRPC6 (0.46) TRPC6CNR2
SCHEMBL23612087 0.94 TRPC6 (0.46) TRPC6CNR2
SCHEMBL23612246 0.89 TRPC6 (0.42) TRPC6CNR2
SCHEMBL23612183 0.87 KDM4E (0.36) TRPC6CNR2
SCHEMBL30021074 0.82 CNR2 (0.38) TRPC6CNR2
SCHEMBL23612025 0.82 CNR2 (0.38) TRPC6CNR2
SCHEMBL23612020 0.82 TRPC6 (0.38) TRPC6CNR2
SCHEMBL23612044 0.81 GCK (0.45) TRPC6CNR2
SCHEMBL23612070 0.76 CNR2 (0.38) CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4085061-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY IFM Due, Inc. (US) 2022-11-09 EP disclosed
WO-2021138419-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY IFM DUE, INC, (US) 2021-07-08 WO disclosed