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TRPC6

Short transient receptor potential channel 6 · Q9Y210 · TRPC6 on Sugi Atlas →

11,652 patent compounds predicted against TRPC6, 4,988 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1939255 SCHEMBL1939255 0.57 19/20
SCHEMBL790364 SCHEMBL790364 0.77 17/20
SCHEMBL806596 SCHEMBL806596 0.74 17/20
SCHEMBL789250 SCHEMBL789250 0.70 17/20
SCHEMBL806707 SCHEMBL806707 0.60 17/20
SCHEMBL788993 SCHEMBL788993 0.68 16/20
SCHEMBL788988 SCHEMBL788988 0.59 16/20
SCHEMBL2409738 SCHEMBL2409738 0.80 15/20
SCHEMBL2411526 SCHEMBL2411526 0.80 15/20
SCHEMBL2411156 SCHEMBL2411156 0.79 15/20
SCHEMBL2411159 SCHEMBL2411159 0.79 15/20
SCHEMBL2409145 SCHEMBL2409145 0.77 14/20
SCHEMBL2369874 SCHEMBL2369874 0.75 14/20
SCHEMBL2370883 SCHEMBL2370883 0.75 14/20
SCHEMBL2410351 SCHEMBL2410351 0.67 14/20
SCHEMBL789564 SCHEMBL789564 1.00 13/20
SCHEMBL806654 SCHEMBL806654 0.75 13/20
SCHEMBL2370480 SCHEMBL2370480 0.73 13/20
SCHEMBL806650 SCHEMBL806650 0.56 13/20
SCHEMBL2409268 SCHEMBL2409268 1.00 12/20

Clinical trials — most relevant to TRPC6 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
TRPV Expression in Subjects With Sensitive Skin PHASE4UNKNOWN
The Re-Prosper HF Study PHASE2/PHASE3COMPLETED
A Study to Find Out if BI 764198 Helps Adults and Adolescents With a Kidney Condition Called Focal Segmental Glomerulosclerosis (FSGS) PHASE3RECRUITING
Role of Intralipid in Management of Organophosphorus Poisoning PHASE2/PHASE3WITHDRAWN
Sodium Citrate in Smell Retraining for People With Post-COVID-19 Olfactory Dysfunction PHASE2ACTIVE_NOT_RECRUITING
Early Study on Tamoxifen Safety/Tolerability in Cystic Fibrosis Patients Unable to Use CFTR Modulators. PHASE2NOT_YET_RECRUITING
TRPM8 Activators for Peripheral Neuropathy PHASE2ACTIVE_NOT_RECRUITING
Influence of Genetics in Pain Sensitivity PHASE2COMPLETED
Assessment of KM-001 - Safety, Tolerability, and Efficacy in Patients With PPPK1 or PC PHASE1COMPLETED
Study Designed to Evaluate Safety and Efficacy of 1% Topical Formulation of KM-001 on Type 1 Punctate Palmoplantar Keratoderma or Pachyonychia Congenita Diseases PHASE1COMPLETED
Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8 EARLY_PHASE1COMPLETED
Mechanisms of Human Heat Perception - Involvement of TRPA1, TRPV1 and TRPM3 EARLY_PHASE1COMPLETED
PET Brain and Whole Body Distribution Studies for Nociceptin/Orphanin FQ Peptide (NOP) Receptor Using [11C]NOP-1A EARLY_PHASE1COMPLETED
Relationship Between Polymorphisms of TRPV1 and KCC2 Gene in Children With Febrile Seizures nanCOMPLETED
Effect of Intraperitoneal Ropivacaine on Visceral Pain After Laparoscopic Gastrectomy nanUNKNOWN
Identification of TRP Channels as New Potential Therapeutic Targets in Primary and Secondary Raynaud's Phenomenon. nanCOMPLETED
Neurogenic Mechanisms in Burning Mouth Syndrome nanCOMPLETED
Factors Affecting Salt Intake in Young Adults nanUNKNOWN
Effects of Photobiomodulation on the Innate Immune System of Neonates and Infants With Bronchiolitis nanUNKNOWN
The Natural History of TRPV4 Neuropathy nanRECRUITING
Mediators in Nasal Hyperreactivity in Allergic Rhinitis and Chronic Rhinosinusitis nanUNKNOWN
Dissecting the Heterogeneity of Oral Cancer Pain nanUNKNOWN
Affective Touch, Hedonia and Suicidal Behavior nanCOMPLETED
Defining TRPV4 Contribution of Schwann Cells to Oral Cancer Pain nanRECRUITING
An Investigation Into the Mechanism of Inhalation Cough Challenge nanCOMPLETED
Qutenza 8% Capsaicin Topical System for the Treatment of Neuropathic Axial Lower Back Pain and Lumbosacral Radiculopathy nanENROLLING_BY_INVITATION
Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle Origin nanENROLLING_BY_INVITATION
Visual Activity Evoked by Infrared in Humans After Dark Adaptation nanCOMPLETED
Genetic Determinants of Sudden Cardiac Death nanCOMPLETED
Pulsed Radiofrequency in Chronic Lumbosacral Radicular Pain nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a TRPC6 binder may also engage these)

ProteinNameSimilarity
Q61143 — 1.000 Q61143 →
Q9MYW0 — 0.999 Q9MYW0 →
TRPC3 Short transient receptor potential channel 3 0.990 landscape →
Q9QZC1 — 0.988 Q9QZC1 →
Q9JMI9 — 0.985 Q9JMI9 →
TRPC7 Short transient receptor potential channel 7 0.977 landscape →
Q9R283 — 0.973 Q9R283 →
Q91YD4 — 0.972 Q91YD4 →
Q9WVC5 — 0.972 Q9WVC5 →
Q9R244 — 0.967 Q9R244 →
E9PTA2 — 0.967 E9PTA2 →
Q9QZ71 — 0.966 Q9QZ71 →
TRPM2 Transient receptor potential cation channel subfamily M member 2 0.964 landscape →
MCOLN3 Mucolipin-3 0.964 landscape →
Q9TU72 — 0.964 Q9TU72 →
A2BIE7 — 0.961 A2BIE7 →
Q9UBH6 — 0.961 Q9UBH6 →
Q9WTN5 — 0.960 Q9WTN5 →
Q9R031 — 0.960 Q9R031 →
Q9Z0U0 — 0.960 Q9Z0U0 →
A7XZ53 — 0.960 A7XZ53 →
Q5RET6 — 0.960 Q5RET6 →
Q9ULQ1 — 0.960 Q9ULQ1 →
Q5ZMP3 — 0.959 Q5ZMP3 →
Q9QZ70 — 0.959 Q9QZ70 →
Q9R032 — 0.958 Q9R032 →
TRPM8 Transient receptor potential cation channel subfamily M member 8 0.958 landscape →
O62826 — 0.958 O62826 →
F6RG56 — 0.957 F6RG56 →
Q4GZT3 — 0.957 Q4GZT3 →